40 THE “ALARMIN” S100 A8: AN ACTIVATOR OF CHONDROCYTE MEDIATED CARTILAGE DAMAGE?
نویسندگان
چکیده
منابع مشابه
Adenosine Pathways Modulate Chondrocyte Mediated Cartilage Degradation
Introduction: The purine base adenosine (ADO) can function as an extracellular signaling molecule and has been reported to reduce inflammation in several in vivo models (1). Adenosine receptor stimulation increases intracellular accumulation of cAMP and suppresses nitric oxide (NO) synthesis by lipopolysaccharide (LPS)and interleukin-1 (IL-1)-stimulated chondrocytes in monolayer culture (2,3). ...
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زمینه و هدف: کالپروتکتین، S100 A8 و S100 A9 در فرآیندهای مهمی نظیر پیام رسانی و تنظیم پاسخ های التهابی نقش دارند. در این مطالعه، بیان S100 A8 و S100 A9 بصورت نوترکیب، خالص سازی و بررسی ساختار آنها انجام گردید. روش کار: در این مطالعه تجربی از pET15b به عنوان حامل توالی کد کننده ژنهای S100 A8, S100 A9 انسانی و از ( E.coli BL21 (DE3 به عنوان میزبان استفاده گردید. بیان ژن و فرآیند خالص سازی از...
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The degradation of proteoglycan was examined in cultured slices of pig articular cartilage. Pig leucocyte catabolin (10 ng/ml) was used to stimulate the chondrocytes and induce a 4-fold increase in the rate of proteoglycan loss from the matrix for 4 days. Material in the medium of both control and depleted cultures was mostly a degradation product of the aggregating proteoglycan. It was recover...
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In a chronically hypoxic tissue such as cartilage, adaptations to hypoxia do not merely include cell survival responses, but also promotion of its specific function. This review will focus on describing such hypoxia-mediated chondrocyte function, in particular in the permanent articular cartilage. The molecular details of how chondrocytes sense and respond to hypoxia and how this promotes matri...
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OBJECTIVE Osteoarthritis (OA) is associated with destruction of type II collagen-rich hyaline articular cartilage. We hypothesized that classical interstitial collagenases cleave collagen type II, leading to the increased expression of the 3/4 native type II collagen fragment (COL2-3/4C) and the corresponding denatured type II collagen fragment (COL2-3/4M), which could correlate with different ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2007
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)61676-8